Although a direct link between SLC8B1 and the biological processes implicated in the onset of MS has not been described, efflux of mitochondrial calcium has been shown to promote the aggregation of the inflammasome, and to regulate the activation of calcium dependent signaling pathways; including the NFATC-mediated non-canonical Wnt pathway (Fig 3) [138–140]. Here, SLC8B1 is linked to myeloid sarcoma.