In addition, significant associations with MS risk, and pathogenic mutations have been described in P2RX4 and P2RX7, non-selective cation channels activated by extracellular ATP [10, 118], and a missense variant in calcium voltage-gated channel subunit alpha1 H (CACNA1H) was found nominally associated with MS clinical course [8]. This evidence concerns the gene P2RX7 and myeloid sarcoma.