Interestingly, the recessive NLRP1 p.Gly578Ser mutation described in a sibling pair diagnosed with MS, and shown to increase IL-1β expression, is also located in the NACHT domain and only seven amino acids N-terminal from the homologous p.Leu475 in NLRP12 (Fig 4) [11]. Here, NLRP1 is linked to myeloid sarcoma.