In addition, significant associations with MS risk, and pathogenic mutations have been described in P2RX4 and P2RX7, non-selective cation channels activated by extracellular ATP [10, 118], and a missense variant in calcium voltage-gated channel subunit alpha1 H (CACNA1H) was found nominally associated with MS clinical course [8]. Here, P2RX4 is linked to myeloid sarcoma.