For SS/HTLV-1 co-infected patients, fewer of the CD3+ and CD8+ cells were within the villi compared to the crypts (comparing Villi to Crypts in co-infected patients CD3+: Villi: 32 [IQR:29.3–41.3]; Crypts: 11.4 [IQR: 9.8–13.8]; Mann-Whitney p = 0.01; CD8+: Crypts: 26 [IQR:23.5–30]; Villi: 14 [IQR: 11.5–18.3]; Mann-Whitney p<0.003, Fig 1B). This evidence concerns the gene CD8A and synovial sarcoma.