Furthermore, we found that inhibition of H19 with siRNA reduced neuronal apoptosis in vitro and in vivo. Recently, Wang et al. reported that H19 could induce cerebral ischemia reperfusion injury via activation of autophagy, and inhibition of H19 could protect neuronal cells from OGD induced death [15]; Zhao et al. reported H19 could induce hippocampal neuronal apoptosis via Wnt signaling, and that inhibition of H19 might serve as a promising novel target for the treatment of cognitive decline in patient with diabetes mellitus [27]. This evidence concerns the gene H19 and Mental deterioration.