RHCG and head and neck squamous cell carcinoma: To determine the prognostic potential of RHCG methylation, the survival curve of 299 HNSCC patients stratified by RHCG methylation level was plotted, it was evident that patients with RHCG hypermethylation had a significantly shorter overall survival time compared with patients with RHCG hypomethylation (p=0.046) (Figure 7I).