RB1 and neoplasm: Tumor-related genes mediate the development of hypertrophic scars in two ways: through mutation of tumor suppressor genes (e.g., P53, Fas, P27, Rb, exon27 and P16) leading to loss of inhibition of fibroblast cell survival and through expression of oncogenes promoting fibroblast cell survival and apoptosis resistance (e.g., c-myc, c-fos, Bcl-2, Tenascin-C) [13–15].