Tumor-related genes mediate the development of hypertrophic scars in two ways: through mutation of tumor suppressor genes (e.g., P53, Fas, P27, Rb, exon27 and P16) leading to loss of inhibition of fibroblast cell survival and through expression of oncogenes promoting fibroblast cell survival and apoptosis resistance (e.g., c-myc, c-fos, Bcl-2, Tenascin-C) [13–15]. This evidence concerns the gene TNC and neoplasm.