Several studies supported BNIP3L involvement in apoptosis and necrosis of cardiomyocyte in heart diseases.47 HIF1b‐dependent BNIP3L increased gene and protein expression has been reported in primary cultured hepatocytes exposed to ethanol and in mice models of alcohol‐induced liver injury and steatosis.48 Although these data support the potential activation of this pathway in liver steatosis, we did not observe its activation in liver biopsies and in in vitro model at intracellular level. This evidence concerns the gene ARNT and heart disorder.