There are no published data on the association between the RAP2A coding gene and NAFLD spectrum; however, it has been reported that in hepatocellular carcinoma, RAP2A regulates MAP4K4, which leads to JNK and NF‐κB signalling activation which are the members of common molecular pathways of NASH pathogenesis. This evidence concerns the gene MAP4K4 and metabolic dysfunction-associated steatotic liver disease.