Zeng et al21 detected 431 differentially expressed circRNAs from CRC tissues of patients with lung metastasis and constructed circRNA/miRNA interactions, They demonstrated that hsa_circ_102761, hsa_circ_086376, and hsa_circ_105055 bonded with miR‐7 and regulated target genes EPHA3, PRKCB, BRCA1, and ABCC1 in CRC with lung metastasis.21 Besides, Zhang et al22 demonstrated that hsa_circ_0020397 regulated CRC cell viability, invasion, and apoptosis by promoting the expression of miR‐138 targets TERT and PD‐L1. This evidence concerns the gene CD274 and colorectal carcinoma.