Du et al35 found that over‐expressed circ‐DNMT1 increased the mRNA level of the parent gene DNMT1. A recent study indicated that circITGA7 inhibited CRC growth and metastasis by modulating Ras pathway and upregulating transcription of its host gene ITGA7. 36 Besides, circEIF3J and circPAIP2 showed interactions with RNA Pol II, U1 snRNP, and parental gene promoters to promote the transcription of host genes.37 These results indicate that some circRNAs can regulate their host genes. The gene discussed is ITGA7; the disease is colorectal carcinoma.