Second, DCA was used in a clinical trial to treat hyperlactatemia, which included patients with septic shock, but did not improve clinical outcome.56 Besides reducing lactate levels, DCA activates the pyruvate dehydrogenase complex (PDC) and stimulates mitochondrial glucose oxidation through increased mitochondrial pyruvate influx.57 DCA in a sepsis mouse model promoted restoration of immunometabolism, increased survival, and improved bacterial clearance.58 New insights and the data presented here suggest that the modulators DCA and NAC might be reconsiderable targets in sepsis treatment. Here, PDC is linked to Sepsis.