PTEN and breast neoplasm: Further RNAPII ChIP-seq experiments revealed significantly higher RNAPII levels at TSS in Pten−/− versus Pten WT MEFs (Supplementary Figure S6A), and at TSS and throughout the entire gene body in MycOE Pten Null versus MycOE Pik3caMut mouse breast tumor cells (Supplementary Figure S6B) (40).