In the present study we provide evidence, in a large cohort of RA patients, that monocyte subset distribution is skewed to a more “pro-inflammatory” profile, with elevated frequency of intermediate monocytes (CD14++CD16+), which were related to the autoimmune and inflammatory profile, the altered microvascular function, the occurrence of early atherosclerosis, and the presence of an increased score of cardiovascular disease risk in this autoimmune disorder. This evidence concerns the gene CD14 and Autoimmunity.