In our hands, CD16+ monocytes displayed a higher number of proinflammatory kinases phosphorylated (i.e., Akt Ser473, Akt Thr308, ERK 1/2, GSK-3β, and p38) than CD14+ monocytes, in accordance with the increased expression of a number mRNAs coding for inflammatory and prothrombotic proteins in CD16+ monocyte subsets of RA patients. This evidence concerns the gene AKT1 and rheumatoid arthritis.