It was suggested that Sishen Needle could regulate platelet 5-HT and plasma ACTH, which is helpful for the symptoms related to CRF.[23] In addition, ST36 is able to Tonify qi and blood, relieve abdominal discomforts and digestive or elimination dysfunctions.[24] Particularly, ST36 regulates immunity and reduces inflammation, which can improve the long term effects cause by related cancer treatments.[25,26] Another recent study concluded that acupuncture at ST36 and PC6 significantly lowered the level of the data of heart rate and oxygen consumption, indicating a fatigue relief.[27]. This evidence concerns the gene POMC and cancer.