In inflammatory bowel disease mice, there was a reduction of CD4+ T cells producing IFN‐γ, an increased frequency of the putative regulatory population of T cells producing IL‐10, and an increment in the frequency of the regulatory markers GITR, CTLA‐4, PD‐1, CD73, and FoxP3, after treating with glucocorticoid (Sales‐Campos et al., 2017). This evidence concerns the gene CD4 and inflammatory bowel disease.