We can also extend our understanding of the relationship between genetics and cortical atrophy beyond APOE to all single nucleotide polymorphisms (SNPs) using multivariate methods such as partial least squares (PLS; Lorenzi et al., 2018) or canonical correlation analysis (Szefer, Lu, Nathoo, Beg, & Graham, 2017). Here, APOE is linked to Cerebral cortical atrophy.