In mutant SOD1 mouse models of ALS that recapitulate several aspects of the disease including neuroinflammation, motor neuron loss and reduced lifespan, deletion of the mutant gene from either astroglia or microglia slows the progression of disease (Boillee et al. 2006; Yamanaka et al. 2008). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.