Somasundaram et al. (24), on the other hand, reported that curcumin had increased apoptosis in human breast cancer cell, whereas Bhaumik et al. (25) reported that curcumin caused an increase in apoptosis on AK5 cell line, and Weir et al. stated that curcumin had increased apoptosis on p53 mAPK line, which was an ovarian cancer model (26). This evidence concerns the gene TP53 and ovarian carcinoma.