Studies have also indicated that the administration of the RXRs (Retinoid X Receptors) and LXRs (Liver X Receptors) agonist increases the ABCA1 and APOE expressions, leads to an increase in the clearance of Aβ by lipidated APOE and causes an improvement in cognitive impairment (34-37). The gene discussed is ABCA1; the disease is Cognitive impairment.