Studies have also indicated that the administration of the RXRs (Retinoid X Receptors) and LXRs (Liver X Receptors) agonist increases the ABCA1 and APOE expressions, leads to an increase in the clearance of Aβ by lipidated APOE and causes an improvement in cognitive impairment (34-37). This evidence concerns the gene APOE and Cognitive impairment.