The EMPA-LEG-OUTCOME, CANVAS, and DECLERE-TIMI58 trials have demonstrated that sodium glucose cotransporter 2 inhibitors (SGLT2-is) can decrease cardiovascular death, cardiovascular events, and renal events in patients with type II diabetes, attracting strong attention among cardiologists [1–3]. Here, SLC5A2 is linked to type 2 diabetes mellitus.