PNN and ischemic stroke: Our first piece of evidence that implicates a role for Pnn in ischemic stroke arises from the significant increase in its expression at the peri-infarct area in the ipsilateral cortex and striatum 6 h and 24 h after transient MCAO, which correlates positively with the time-course of the induced infarction detected by T2WI and TTC stain.