GLP1R and type 2 diabetes mellitus: Current diabetes guidelines recommend multifactorial CV risk management and the preferential use of a glucagon-like peptide-1 receptor agonist (GLP-1RA) or sodium–glucose cotransporter-2 inhibitor with proven CV benefits as a first choice add-on to metformin in patients with T2D and established atherosclerotic CVD [2, 4].