Patients carrying the minor allele of EDN3 rs260741 (AA/AG vs. GG), rs197173 (TT/TG vs. GG), and rs926632 (CC/CT vs. TT) had a lower risk of hospitalized bacteremia events (genotype model, dominant model, and allelic model P value < 0.05). This evidence concerns the gene EDN3 and bacterial infectious disease with sepsis.