CD40LG and colorectal carcinoma: When comparing the secretion of primary CRC tumors to that of the matching metastases, in general, primaries tend to have a higher overall Ig secretion (29.2 vs. 5.5, 3.1 vs. 0.5, and 13.8 vs. 3.5 average specific spots for IgA, IgM, and IgG, respectively).