Immunoblotting of DLBCL cell lines exposed to PQR620 (2 μM, 24 h) showed reduction of p-p70 S6 (Thr389) and p-4e-BP1 (Thr37/46) levels, indicative of TORC1 inhibition, and of p-AKT (Ser 473), indicative of TORC2 inhibition (Figure 1). The gene discussed is CRTC1; the disease is diffuse large B-cell lymphoma.