TP53 and hyperinsulinemic hypoglycemia, familial, 4: Moreover, because most genomic alterations associated with OvC (TP53 mutations, copy number alterations, DNA repair deficiency) can be identified in precursor lesions called STICs (serous tubal epithelial carcinomas), monitoring of these alterations for patients at a high risk of OvC (such as BRCA1/2 mutation carriers) may improve early diagnosis for these patients and may allow prevention by adnexal removal [45].