Using this model, they overexpressed PDGF–B (a proneural tumor driver), TAZ, or PDGF–B plus TAZ in neural progenitor cells observing that mice overexpressing PDGF-B developed tumors with PN characteristics (predominantly grade II), those overexpressing TAZ were not able to drive tumor formation, but the combination of the two lead to the formation of grade III and IV tumors with a high expression of MES markers (FN1, CD44, and CTGF), thus providing an in vivo proof that TAZ is able to contribute to drive tumors towards a MES phenotype. This evidence concerns the gene CCN2 and neoplasm.