Importantly, experiments performed with FVB/N mice allografted with PDGFRα+ proneural high-grade glioma cells showed that mice treated with AZD1480 in combination with radiation had a stronger benefit in terms of survival with respect to those subjected to radiation treatment alone, thus further sustaining a central role for STAT3 in PMT–dependent cell aggressiveness [40]. Here, STAT3 is linked to central nervous system cancer.