IGHE and allergic disease: In a murine model of OVA-induced allergic airway inflammation (OVA-AAD), Mathias et al., reported that depletion of NK cells significantly impaired the development of OVA-AAD by preventing the secretion of Th2 cytokines, the generation of OVA-specific IgE antibodies, and the infiltration of T cells and eosinophils to the lungs [153], suggesting that NK cells play a pro-inflammatory role in allergic disease.