Similarly, heterogeneous nuclear ribonucleoproteins (hnRNPs) A2B1 and A1 (hnRNPA2B1 and hnRNPA1) with ALS-related point mutations in their prion-like domains noticeably alter SG biogenesis and dynamics, being excessively incorporated into this PMLO [159]. This evidence concerns the gene HNRNPA2B1 and amyotrophic lateral sclerosis.