In Ewing sarcoma, EWSR1-FLI1 fusion protein phase-separates (via the prion-like domain of EWS) and specifically targets the BRG1/BRM-associated factor (BAF) chromatin remodeling complex to tumor-specific enhancers and contributes to target gene activation, thereby eliciting the aberrant transcriptional programs underlying Ewing’s sarcoma [172,179]. The gene discussed is EWSR1; the disease is neoplasm.