Examples of systems undergoing dynamic LGPS include heterotypic polymerization of the LCD of the fused in sarcoma (FUS) RNA-binding protein with RNA [119]; polymerization of mutant FUS forms associated with amyotrophic lateral sclerosis (ALS) [121]; RNA-dependent hydrogel formation of the LCDs of CIRBP, RBM3, hnRNPA1, hnRNPA2, yeast Sup35 protein [119,122], Ewings sarcoma (EWS), and TAF15 proteins [120]; and FG-rich repeat regions of some nucleoporins, such as yeast nucleoporin Nsp1p [118]. The gene discussed is EWSR1; the disease is amyotrophic lateral sclerosis.