NUP98 and leukemia: Importantly, although large puncta formed by the NUP95 and its FG-repeat domain are not related to hematopoietic cell transformation and leukemia development [168], the NUP98-based FOs form, through phase separation, many chromatin-associated, sub-micron-sized puncta that are associated with aberrant gene transcription, hematopoietic cell transformation and pathogenesis of leukemia [166].