TP53 and cancer: Each cluster had a function that is closely associated with common cancer relation pathogenesis: Cluster 1 consisting of nine T-UCRs was associated with DNA damage response (TP53 responsive); Cluster 2, comprised of 11 T-UCRs, was associated with cell cycle regulation and proliferation; Cluster 3, containing nine T-UCRs, was associated with p53-dependent neuronal differentiation; and Cluster 4, involving six T-UCRs, was associated with immune response and development.