Additionally, the authors also validated the involvement of T-UCRs in p53 activation using neuroblastoma cells following the inhibition of p53 with the lentiviral shRNA system and treatment with nutlin, a small molecule that activates p53 by inhibiting the interaction between MDM2 and p53 [42,43], which showed that 29 out of 40 T-UCRs are p53 responsive. This evidence concerns the gene TP53 and neuroblastoma.