KLK3 and Familial prostate cancer: Some serum glycoprotein biomarkers, such as carcino-embryonic antigen (CEA), carbohydrate antigens 19-9 (CA19-9) and 125 (CA125), alpha-fetoprotein (AFP), and prostate-specific antigen (PSA) have been found to be useful in the initial detection of colon, ovarian, and prostate cancers [79].