Since the G allele of Cdx2 decreases the VDR gene transcription [50], haplotypes containing G allele are expected to be associated with increased risk of breast cancer; however G allele containing haplotypes including the FTCG haplotype in the Abbas study and GfbAt, Gfb and GfT in the current study were accompanied with decreased risk of breast cancer and better response to vitamin D3 supplementation, respectively [50,51,52]. The gene discussed is VDR; the disease is breast cancer.