VDR and breast cancer: Despite extensive research on the roles of vitamin D or VDR per se in carcinogenesis [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,18,19,20] to date, no controlled trial has been performed to investigate the possible biological interactions of the VDR genetic variations with vitamin D intake on diverse aspects of the breast cancer host response.