These SVs were distinct from p53−/− lymphoma rearrangements by four apparent criteria: (1) they were primarily intra-chromosomal inversions (59 SVs; 60%) (Figures S5A and S5B); (2) they contained inter-chromosomal rearrangements (5 translocations; 5%) (Figure S5B); (3) they lacked RSS-like motifs at the breakpoint junctions (agnostic motif search, data not shown); and (4) the majority of resolved amplicon-associated SVs showed evidence of short base-pair homology at the breakpoint junction (Figure S5C). Here, TP53 is linked to lymphoma.