RAG2 and cancer: Among the 11 putative or known cancer genes we identified in the amplicon, seven were differentially expressed in Rag2−/−p53−/− tumors (Figure 4E), with five genes overexpressed (DDX6, ETS1, HINFP, MLL/KMT2A, and PAFAH1B2) in Rag2−/−p53−/− tumors as compared to both p53−/− tumors and wild-type thymocytes (Figure 4F).