High score of CD8+ TILs (graded as 3+) is almost always seen only in tumors with high HLA-1 expression, although some HLA-1 high-expressing tumors contain low levels of CD8+ TILs (S1B and S1C Fig), suggesting that tumor HLA-1 expression is required but not sufficient for CD8+ cell infiltration in TME. The gene discussed is CD8A; the disease is neoplasm.