MICA and hepatocellular carcinoma: Similarly, a case-control study of a Han Chinese reported that MICA A5.1 was associated with a 47% increase in hepatocellular carcinoma [26], while in a Japanese case-control study, having MICA A5.1 allele was associated with a 37% increase in oral squamous cell carcinoma risk, and significantly higher s-MICA levels in cases than in healthy controls[22].