NGL-3 interacts with presynaptic leukocyte common antigen-related (LAR) family receptor tyrosine phosphatases (LAR-RPTPs; LAR, protein tyrosine phosphatase σ [PTPσ], and protein tyrosine phosphatase δ [PTPδ]) [20, 21], which have been implicated in diverse psychiatric disorders and are known to regulate both early neurodevelopmental processes and postnatal synapse development [1, 4]. The gene discussed is PTPRF; the disease is psychiatric disorder.