AKT1 and early-onset autosomal dominant Alzheimer disease: In addition, the altered Akt/GSK3β signaling in Ngl3−/− mice, known to affect numerous synaptic and non-synaptic target proteins and be associated with various brain disorders, including schizophrenia, Alzheimer disease, and bipolar disorder [72, 90–94], may alter the synaptic, neuronal, and circuit functions.