In addition, although NGL-3 has not been directly implicated in any brain disorders, its presynaptic binding partners such as LAR-RPTPs have been strongly associated with various brain disorders [1, 4], including restless leg syndrome [42–44], ADHD [45], autism spectrum disorder (ASD) [46], and bipolar disorder [47]. The gene discussed is PTPRF; the disease is restless legs syndrome.