The analyzed series in the occasion of the abdominoplasty had a mean BMI compared to the moderate level of obesity and the inflammatory markers IL6 and CRP showed a low inflammatory level, and the postoperative modifications demonstrated an increase of these markers, but overall, of the IL4 andIL10 anti-inflammatories, also noting that the HOMA still was elevated. The gene discussed is IL4; the disease is obesity due to melanocortin 4 receptor deficiency.