Compared with model group, the gene expression of Wnt2 and β-catenin mRNA in bone tissue of each dose group of APS rats were significantly increased (p<0.01), and the gene expression of LRP5 mRNA was also significantly increased (p<0.01), but the gene expression of FOXO3a mRNA of the middle- and high-dose APS groups (800mg/kg dose) was significantly increased (p<0.01, Fig. 4). The gene discussed is FOXO3; the disease is autoimmune polyendocrinopathy.