In this sense, to investigate the role of β-AR in cardioprotection, we studied the effects of agonists and antagonist of β-AR on the cardiac arrhythmias, lethality (LET) and serum levels of cardiac injury markers in spontaneously hypertensive (SHR) and normotensive (NWR) rats submitted to CIR. The gene discussed is ADRB2; the disease is chronic obstructive pulmonary disease.