FOXP3 and colorectal carcinoma: These IL-17+ FOXP3+ Tregs express RORγt and exert immunosuppressive function, yet they display compromised anti-inflammatory properties and are pathogenic in the context of CRC.27 Interestingly, in mice challenged with ovarian cancer or CRC cells, Th17 (IL-17A+ FOXP3−) and IL-17A+ FOXP3+ cells can transdifferentiate into IL-17A-negative CD4+ FOXP3+ T cells with immunosuppressive function.