In addition, the frequency of CD4+ FOXP3+ Tregs, the proportion of ST2+ CD4+ FOXP3+ Tregs, and IL-33 protein expression in the colon all positively correlated with tumor scores (i.e. the sum of the relative size of all tumors in a given mouse), irrespective of the genetic background (Fig. 2e, f). Here, CD4 is linked to neoplasm.