Importantly, frequency of ST2+ CD4+ FOXP3+ Tregs—but not of CD4+ FOXP3+ Tregs—also correlated with intestinal tumorigenesis in other murine models of CRC based on mutation in the Apc gene or on intestinal-specific deficiency in mismatch repair (Fig. 2g, h and Supplementary Fig. 1D–G). Here, APC is linked to colorectal carcinoma.