CD4 and colorectal carcinoma: To also address the specific contribution of ST2 on CD4+ FOXP3+ Tregs to CRC, we generated mixed BM chimeras by reconstituting WT recipient mice with equal ratios of BM cells from WT and Foxp3DTR mice (WT:Foxp3DTR) or from St2−/− and Foxp3DTR animals (St2−/−:Foxp3DTR).