CD4 and colorectal carcinoma: Moreover, several chemokine receptors including CCR4, CCR5, CCR9, CXCR3, and the integrins α-E/CD103 and α-V (which are encoded by Itgae and Itgav, respectively) showed increased expression on ST2+ versus ST2− CD4+ FOXP3+ Tregs isolated from CRC lesions (Fig. 4g–l).