Loss of TG2 did not affect the obesity-related alterations in the expression levels of the adiponectin and resistin (Fig. 1c), but obesity-induced expressions of TNF-α, MCP-1, and leptin were significantly enhanced in the gWAT adipocytes of TG2 null animals as compared to wild type mice (Fig. 1c). This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.