LncRNA regulates neuronal apoptosis seen in several studies21, for example, overexpression of lncRNA MALAT1 can inhibit glaucoma-induced neuron apoptosis through activation of PI3K/Akt-signaling pathway22; overexpression of lncRNA Rpa promote lead-induced neuronal apoptosis through PI3K/Akt-signaling pathway23. The gene discussed is AKT1; the disease is glaucoma.