1988). ANG II is a potent vasoconstrictor and the RAAS main effector peptide which interacts with G‐protein‐coupled receptor AT 1. ANG II pathological activities are related to fibrotic processes, glomerular diseases, hypertension and diabetes (Wolf 1995; Mezzano et al. 2001; Fyhrquist and Saijonmaa 2008; Ruster and Wolf 2013). This evidence concerns the gene AGT and hypertensive disorder.