CD44 and neoplasm: In this study, we collected the general clinical data of 79 LARC patients, examined the expression of the CD44 spliced variant CD44v6, a tumor stem cell marker, in primary tumors, according to the results of Huh et al. in screening for predictors of tumor regression after preoperative CCRT for rectal cancer [3], obtained eight direct or derivative volumetric imaging parameters and analyzed the correlativity between the pCR and these factors, in order to provide guidance for clinial practice.