Another phase 1b/2 trial is studying biomarker-based treatment of AML more broadly by using genomic screening to identify specific subtypes of AML (including IDH2-mutant) and assign each subtype to a distinct treatment regimen—IDH2-mutant AML will be assigned to Enasidenib treatment (ClinicalTrials.gov NCT03013998). Here, IDH2 is linked to acute myeloid leukemia.