IDH2 and acute myeloid leukemia: Shortly after the 2017 phase 1 Enasidenib trial in AML, an independent differentiation syndrome review committee (DSRC) retrospectively analyzed possible cases of IDH-DS, identified distinguishing characteristics of patients who developed IDH-DS, such as fewer previous anticancer therapies and higher baseline peripheral blasts and lactate dehydrogenase levels, and outlined an easy-to-follow protocol for IDH-DS diagnosis and management (105).