IDH2 and cancer: Nevertheless, while the mutant IDH enzyme can exist either as a homodimer or as a heterodimer with the wild-type IDH within cancer cells, all reported oncogenic IDH mutations to date are genetically heterozygous, suggesting that the critical role of mutant IDH is related to its gain-of-function for conversion of the wild-type IDH product, α-ketoglutarate, to 2HG (20).