Shortly after the approval of Enasidenib, its mutIDH1 counterpart, Ivosidenib, similarly demonstrated safety and clinical efficacy in a phase 1/2 dose-escalation/dose-expansion trial of relapsed/refractory IDH1-mutant AML (ClinicalTrials.gov NCT02074839) (13). This evidence concerns the gene IDH1 and acute myeloid leukemia.