Biochemical:IDH1R132H: 15 nMIDH1R132C: 15 nMCell-Based:LN299 (IDH1R123H): 73 nMHCT-116 (IDH1R132H): 47 nMHT1080 (IDH1R132C): 135 nMNCH551b (GBM) (IDH1R132H): 13 nM AML (patient-derived)IDH R123H: 5 nMIDH R123C: 5 nMIDH R123G: 4 nMIDH R123S: 16 nMIDH R123L: 3 nM. Here, IDH2 is linked to acute myeloid leukemia.