KLF1 and acute myeloid leukemia: Additional studies have demonstrated that AGI-6780 is not only capable of promoting the expression of differentiation markers such as hemoglobin gamma (HBG) and Kruppel-like factor 1 (KLF1), but that it does so by reversing 2HG-induced DNA and histone hypermethylation in AML cellular models—thereby suggesting that AGI-6780 can manipulate key mechanisms of oncogenesis (72, 74).