Two trials, a phase 1b/2 and a phase 2, are evaluating Enasidenib in combination with a DNA methyltransferase (DNMT) inhibitor, azacitidine, in newly-diagnosed and relapsed/refractory AML, respectively (ClinicalTrials.gov NCT02677922, NCT03683433). The gene discussed is DNMT1; the disease is acute myeloid leukemia.