Since the success of the Enasidenib phase 1/2 trial in myeloid malignancies and FDA approval for the indication of relapsed/refractory IDH2-mutant AML was obtained in 2017, clinical trials investigating the efficacy of mutIDH2 inhibitors, mostly Enasidenib, in various AML subpopulations have become abundant. This evidence concerns the gene IDH2 and acute myeloid leukemia.