Further, within these various populations, phenotypic, functional, and activation/exhaustion proteins with broad or restricted distribution could be identified, including high expression of PD1 in tumor infiltrating CD4 T cells and Tregs, with less PD1 expression observed in CD8 T cells, high level, and broad CD95 (Fas) and CD39 expression across many populations of tumor-infiltrating cells (although the latter was largely absent from CD8 T cells), and restricted expression of granzyme B, primarily by CD8 T cells (Figure 5A). This evidence concerns the gene PDCD1 and neoplasm.