It is noteworthy that some researchers have found that the expression of HOXA6 in CRC tumor tissue was higher than that in adjacent normal tissue and HOXA6 can serve as a tumor promoter in CRC (34), in our study we only found HOXA6 methylation was associated with age, KRAS mutation and its downregulation in early stage CRC. The gene discussed is HOXA6; the disease is colorectal carcinoma.