Howerver, no such perfect results are presented on the HOXA5 and HOXA6 genes, although in general the HOXA5 and HOXA6 genes are significantly methylated in tumor tissues (Supplemental Table 2), which may be due to the larger CpG island region of HOXA5 and HOXA6 and also indicates that HOXA2 gene hypermethylation is more obvious in colorectal cancer. This evidence concerns the gene HOXA6 and colorectal cancer.