The interim subgroup analysis from a prospective phase II trial evaluating RT-cetuximab vs. CRT with weekly cisplatin in LA-HNSCC showed a trend favoring the cisplatin arm in all outcome parameters including LRC, PFS and OS in the p16-positive group (NCT01216020) (110). The gene discussed is CDKN2A; the disease is head and neck squamous cell carcinoma.