The Keap1/Nrf2/ARE pathway plays a major role in health resilience including inflammatory diseases [65], neurodegenerative diseases [66], PD [67], AD [68], stroke [69], chronic kidney disease [70], atherosclerosis [71], diabetes [72], cardiovascular diseases [73] and rheumatoid arthritis [74]. The gene discussed is NFE2L2; the disease is cardiovascular disorder.