Additionally, a genetic disease known as hereditary sensory neuropathy (HSN) or hereditary sensory and autonomic neuropathy (HSAN) was initially believed to be caused by a mutation in a single exon open reading frame (ORF) located within intron 8 of the WNK1 allele, termed “HSN2” [73]. The gene discussed is WNK1; the disease is hereditary sensory and autonomic neuropathy.