We found that serum IL-4 level was significantly lower in AIS patients with poor outcome compared with those with a good prognosis 3.10 (IQP 1.13 - 8.15) pg/mL vs. 0.53 (IQR 0.28 - 1.32) pg/mL, P < 0.001), IL-5 level also significantly decreased in the poor outcome group [0.63 (IQR 0.48 - 0.86) pg/mL vs. 0.32 (IQR, 0.24 - 0.66) pg/mL, P < 0.001] (Fig. 2). Here, IL4 is linked to androgen insensitivity syndrome.