We found that serum concentration of IL-5 functioned as a protective factor and was an independent predictor for functional outcome of AIS patients with an adjusted OR of 0.039 (95% CI, 0.003 - 0.475, P = 0.011), whereas IL-6 was an independent risk factor in functional outcome with an adjusted OR of 1.329 (95% CI,1.095 - 1.612, P = 0.004). Here, IL5 is linked to androgen insensitivity syndrome.