Using both a breast cancer-directed 8-gene signature (EMT8) and a generic 315-gene signature (EMT315), EMT was found to be particularly associated with reduced SDHC expression in the n = 204 cohort, with a Rho value of − 0.422 (p < 0.0001) using the EMT8 signature (Fig. 1a) and Rho value of − 0.55 (p < 0.0001) using the EMT315 signature (Fig. 1b). This evidence concerns the gene SDHC and breast cancer.