Gene expression analysis on the Affymetrix breast cancer cohort confirmed that downregulation of SDHA, SDHB, SDHC, and/or SDHD is associated with increased expression of EMT and invasion/migration markers and pointed to specific genes that may link to accompanying effects on energy metabolism, mitochondrial quality control, and antioxidant systems to the induction of EMT (Fig. 7). The gene discussed is SDHD; the disease is breast cancer.