SDHD and breast carcinoma: Gene expression analysis on the Affymetrix breast cancer cohort confirmed that downregulation of SDHA, SDHB, SDHC, and/or SDHD is associated with increased expression of EMT and invasion/migration markers and pointed to specific genes that may link to accompanying effects on energy metabolism, mitochondrial quality control, and antioxidant systems to the induction of EMT (Fig. 7).