Interestingly, RPCI-WM1 cells secrete the highest levels of IgM among the available WM cell lines (data not shown), and in our studies, the average IgM levels in RPCI-WM1 tumor-bearing mice was higher (Control mice: 59.39 ± 0.927 and Tocilizumab treated mice: 60.46 ± 1.025 μg/ml) than in BCWM.1 tumor-bearing mice (Control mice: 18.8 ± 4.17 and Tocilizumab treated mice: 11.32 ± 1.64 μg/ml) (Table 1). The gene discussed is CD40LG; the disease is neoplasm.